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Humulin R, Regular, insulin human injection, USP, recombinant DNA origin

National Museum of American History

Object Details

Eli Lilly and Company
Description (Brief)
Humulin is human insulin used for treating diabetes. Prior to its development, diabetics used insulin isolated from pig and cow pancreases. Developed by Genentech, the first American biotechnology company, Humulin was licensed to Eli Lilly and became the first marketable product created through recombinant DNA technology. Its licensing by the FDA in October 1982 also made it the first recombinant pharmaceutical approved for use in the United States.
Recombinant pharmaceuticals are created by inserting genes from one species into a host species, often yeast or bacteria, where they do not naturally occur. The genes code for a desired product, and therefore the genetically modified host organisms can be grown and used as a kind of living factory to produce the product. In this case, genes coding for human insulin are inserted into bacteria. Bacteria produce insulin, which is harvested and used as the active ingredient in Humulin.
Humulin R is considered to be "regular" insulin and has had nothing added to change the speed or length of its action. It takes effect rapidly and has a relatively short duration of activity (6 to 8 hours) as compared with other insulin formulations.
Object consists of a white cardboard box with black and red printing. Box contains two product inserts and one round clear glass bottle with an orange plastic cap and a white label. Bottle contains a yellowish, clear solution.
Location
Currently not on view
Credit Line
Eli Lilly and Company (through Carol Edgar)
1987
ID Number
1987.0790.03
accession number
1987.0790
catalog number
1987.0790.03
Object Name
humulin
biological, human insulin
pharmaceutical
biological
human insulin
Physical Description
human insulin (drug active ingredients)
cardboard (container material)
paper (container material)
glass (container material)
Measurements
overall: 2 3/4 in x 1 5/16 in x 1 5/16 in; 6.985 cm x 3.33375 cm x 3.33375 cm
place made
United States: Indiana, Indianapolis
See more items in
Medicine and Science: Medicine
Health & Medicine
Biotechnology and Genetics
Recombinant Pharmaceuticals
Science & Mathematics
Diabetes
National Museum of American History
Record ID
nmah_1000969
Metadata Usage (text)
CC0
GUID (Link to Original Record)
https://n2t.net/ark:/65665/ng49ca746a8-7784-704b-e053-15f76fa0b4fa

Related Content

  • Insulin and Diabetes Management

    American History Museum
  • Recombinant DNA and the Birth of Biotech

    American History Museum
Humulin R, Regular
There are restrictions for re-using this image. For more information, visit the Smithsonian's Terms of Use page .
International media Interoperability Framework
IIIF provides researchers rich metadata and media viewing options for comparison of works across cultural heritage collections. Visit the IIIF page to learn more.
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